Activation of Neutrophil Collagenase in Periodontitis

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منابع مشابه

Activation of neutrophil collagenase in periodontitis.

Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontitis whereas the latent enzyme is predominant in gingivitis. Since the activatio...

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Neutrophil hyper-responsiveness in periodontitis.

Peripheral neutrophil hyper-responsiveness in chronic periodontitis leads to excessive reactive oxygen species (ROS) production. We aimed to determine whether neutrophil hyper-responsiveness was constitutive or reactive, and to discover the effect of non-surgical therapy. Peripheral blood neutrophils from patients (n = 19), before and 3 months after therapy, and matched control individuals were...

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Human neutrophil collagenase cleaves x 1 - antitrypsin

Inactivation of the plasma serine-proteinase inhibitor a1-antitrypsin (a1-AT) by neutrophil metalloproteinases has been reported [Vissers, George, Bathurst, Brennan & Winterbourn (1987) Fed. Proc. Fed. Am. Soc. Exp. Biol. 46, 1390a; (1988) J. Clin. Invest. 82, 706-711; Desrochers & Weiss (1988) J. Clin: Invest. 81, 1646-1650]. To identify the enzyme responsible, supernatant from neutrophils sti...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1999

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.67.5.2319-2326.1999